Brice Korkmaz Selected Research

Myeloblastin (Proteinase 3)

1/2020	4C3 Human Monoclonal Antibody: A Proof of Concept for Non-pathogenic Proteinase 3 Anti-neutrophil Cytoplasmic Antibodies in Granulomatosis With Polyangiitis.
1/2019	Premedication with a cathepsin C inhibitor alleviates early primary graft dysfunction in mouse recipients after lung transplantation.
10/2018	Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis.
1/2018	Exploiting the S4-S5 Specificity of Human Neutrophil Proteinase 3 to Improve the Potency of Peptidyl Di(chlorophenyl)-phosphonate Ester Inhibitors: A Kinetic and Molecular Modeling Analysis.
1/2016	Inhibitors and Antibody Fragments as Potential Anti-Inflammatory Therapeutics Targeting Neutrophil Proteinase 3 in Human Disease.
9/2013	A monoclonal antibody (MCPR3-7) interfering with the activity of proteinase 3 by an allosteric mechanism.
7/2013	Neutrophil proteinase 3 and dipeptidyl peptidase I (cathepsin C) as pharmacological targets in granulomatosis with polyangiitis (Wegener granulomatosis).
1/2013	Selective inhibitors of human neutrophil proteinase 3.
9/2011	A substrate-based approach to convert SerpinB1 into a specific inhibitor of proteinase 3, the Wegener's granulomatosis autoantigen.
12/2010	Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases.

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Brice Korkmaz Research Topics

Disease

14	Granulomatosis with Polyangiitis (Wegener's Granulomatosis) 01/2021 - 12/2008
10	Inflammation (Inflammations) 01/2020 - 09/2002
7	Vasculitis (Vasculitides) 01/2022 - 12/2010
4	Autoimmune Diseases (Autoimmune Disease) 11/2020 - 01/2017
3	Infections 01/2020 - 01/2013
2	Neoplasms (Cancer) 12/2021 - 02/2014
2	Neoplasm Metastasis (Metastasis) 12/2021 - 01/2018
2	COVID-19 04/2021 - 11/2020
2	Pneumonia (Pneumonitis) 04/2021 - 06/2005
2	Ischemia 01/2019 - 01/2018
2	Primary Graft Dysfunction 01/2019 - 01/2018
2	Cystic Fibrosis (Mucoviscidosis) 01/2018 - 08/2006
2	Lung Diseases (Lung Disease) 04/2016 - 03/2012
2	Autosomal Recessive 3 Severe Congenital Neutropenia 12/2010 - 03/2007
2	Neutropenia 08/2009 - 03/2007
1	Vascular System Injuries 01/2022
1	Glomerulonephritis 01/2022
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2022
1	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis 01/2022
1	Bronchiectasis 12/2021
1	Lung Injury 11/2020
1	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2020
1	Rheumatoid Arthritis 01/2019
1	Arthritis (Polyarthritis) 01/2019
1	Immune System Diseases (Immune Disorders) 10/2018
1	Osteoporosis 01/2018
1	Reperfusion Injury 01/2018
1	Urinary Bladder Neoplasms (Bladder Cancer) 11/2014
1	Granuloma 12/2013
1	Systemic Vasculitis 12/2013
1	Autolysis 12/2012
1	Asthma (Bronchial Asthma) 08/2011
1	Hermanski-Pudlak Syndrome (Hermansky-Pudlak Syndrome) 03/2007
1	Cyclic neutropenia 03/2007
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 06/2005

Drug/Important Bio-Agent (IBA)

14	Peptide Hydrolases (Proteases)FDA Link 12/2021 - 10/2002
12	Myeloblastin (Proteinase 3)IBA 01/2020 - 12/2008
11	Serine Proteases (Serine Protease)IBA 01/2022 - 02/2008
8	Leukocyte Elastase (Neutrophil Elastase)IBA 01/2020 - 08/2006
7	Cathepsin CIBA 01/2022 - 07/2013
6	Antineutrophil Cytoplasmic Antibodies (ANCA)IBA 01/2022 - 07/2009
6	AutoantigensIBA 01/2020 - 07/2010
5	Pancreatic Elastase (Elastase)IBA 11/2020 - 06/2005
4	AutoantibodiesIBA 11/2014 - 12/2008
3	AntibodiesIBA 01/2016 - 09/2013
2	Cathepsin GIBA 01/2020 - 09/2002
2	AntigensIBA 10/2018 - 12/2008
2	Biological ProductsIBA 11/2014 - 09/2011
2	Proteins (Proteins, Gene)FDA Link 08/2009 - 03/2007
1	Bile Acids and Salts (Bile Acids)IBA 01/2022
1	brensocatibIBA 12/2021
1	NitrilesIBA 12/2021
1	Biomarkers (Surrogate Marker)IBA 01/2021
1	EnzymesIBA 01/2020
1	Serine EndopeptidasesIBA 01/2020
1	Monoclonal AntibodiesIBA 01/2020
1	CollagenIBA 01/2019
1	CathepsinsIBA 01/2018
1	PerfadexIBA 01/2018
1	Proto-Oncogene Proteins c-sis (Platelet Derived Growth Factor B)IBA 02/2014
1	Chymotrypsin FDA Link 12/2012
1	SolutionsIBA 03/2012
1	Tissue ExtractsIBA 08/2011
1	Chymases (Chymase)IBA 08/2011
1	Tryptases (Tryptase)IBA 08/2011
1	EpitopesIBA 07/2010
1	Pharmaceutical PreparationsIBA 08/2006
1	depelestatIBA 08/2006
1	AerosolsIBA 08/2006
1	inter-alpha-inhibitorIBA 08/2006

Therapy/Procedure

4	Therapeutics 01/2022 - 09/2011
2	Lung Transplantation 01/2019 - 01/2018
1	Premedication 01/2019